CQuell and the ECS Complex

Cannabis Derived. Dermatologist Approved.

The CQuell story starts in 2016 when our team of researchers, physicians, compounding pharmacists and other scientists came together to approach an ambitious project: which components of the cannabis sativa plant could be used to help people and how? Can this be accomplished while avoiding intoxicating effects? We were surprised by one of the results: the plant and seed oils, along with specific terpenes and other naturally occurring cannabis-derived molecules could be soothing when applied to dry, sensitive, and itchy skin. This revelation sparked four years of research, culminating with the launch of CQuell.

In our search for answers, we reviewed published, peer-reviewed studies and research that focus on the benefits of cannabis and hemp and found the data suggest that cannabinoids, terpenes and other cannabis-derived molecules represent some of the most biocompatible oils and lipids found in nature, but cannabis also contains intoxicating substances and irritating, harsh and fragrant compounds. Two classes of the compounds that carried compelling data that may require more explanation are cannabinoids and terpenes.

Cannabinoids

More specifically, phytocannabinoids represent a group of compounds found in the cannabis sativa plant (hemp). Phytocannabinoids have also been reported in plants from the genus’ Radula (a leafy moss-like plant) and Helichrysum1 (a group of plant species that share the same family as sunflowers) but the search for non-cannabis sources of cannabinoids is just beginning. Of the 100+ identified phytocannabinoids produced by the hemp plant, CBD and THC are two of the most abundant. Because these compounds were first discovered within the cannabis plant, they inherited the name of the plant in their classification, thus cannabinoids from cannabis. With the discovery of the endocannabinoid system, the vast network of receptors throughout the human body that includes endogenous (occurring naturally within the body) cannabinoid receptor ligands, the term “phytocannabinoids” was proposed for the particular cannabinoid compounds found in cannabis and now also extends to these same compounds as they continue to be discovered in other plant forms.

Terpenes

Terpenes are plant and fruit derived molecules responsible for scent. The identifiable scent of pine, citrus, lavender, chamomile, cinnamon and black pepper each stem from the plant’s terpene profile. Terpenes are the primary constituents of most essential oils and frequently used as natural fragrances. Each cannabis variety (often referred to as strain, although this term is technically appropriate for bacteria, not plants) has its own signature blend of terpenes, but most contain high levels of myrcene and pinene, which gives cannabis its characteristic scent. While some terpenes like bisabolol (derived primarily from chamomile, but also found in certain hemp varieties) have been shown to soothe sensitive skin, many terpenes will irritate human skin. The Environmental Working Group (EWG) requires that products containing cinnamal, citral, eugenol, geraniol, farnesol, and linalool (just to name a few) must carry a statement of potential allergy warning on their labels.

Key Ingredients in the ECS ComplexTM

While the various therapeutic compounds found in the cannabis sativa plant offer promise in many commercial areas, formulations for sensitive skin require extensive knowledge and research. When extracted, isolated, carefully selected and then re-combined in the correct ratios, these beneficial plant-derived compounds act to reinforce the skin’s natural barrier function and soothe dry, irritated and sensitive skin. CQuell is the result of this careful analysis and formulation process. We have researched an ideal blend of cannabinoids, terpenes, and biomimetic molecules to soothe sensitive skin.

Our patent-pending Exclusive Cannabinoid Synergy (ECS) ComplexTM leverages the benefits of five key ingredients:

  • Hemp Oil: Hemp oil is extracted from varieties of the cannabis sativa plant that contain less than 0.3% THC. It has no intoxicating effects but contains naturally occurring CBD.
  • Hemp Seed Oil: Oil from the seeds of the hemp plant that has an ideal ratio of linoleic to oleic fatty acids.
  • Bisabolol: A terpene found in many plants including hemp and chamomile flowers, bisabolol has been shown to soothe sensitive skin
  • Palmitamide MEA: Palmitamide MEA is a synthetic form of PEA, an endocannabinoid or a cannabinoid that occurs naturally in all mammals. Palmitamide MEA is biomimetic, meaning that it mimics the biochemistry of the human body. It is extensively used and tested in formulations for sensitive and dry, itchy skin.
  • Cannabidiol (CBD): CBD is a naturally occurring cannabidiol that is found in the cannabis sativa plant.

1) Frontiers in Plant Science, February 2016, pages 1-17


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